6533b821fe1ef96bd127c205
RESEARCH PRODUCT
Stability of Alkyl Chain-Mediated Lipid Anchoring in Liposomal Membranes
Andrea TuettenbergEyleen BeckerNiklas ZimmerMark HelmHolger FreyLukas GleueJonathan Schuppsubject
0301 basic medicineGlycerolliposomesPolymers02 engineering and technologyMicelleArticle03 medical and health scienceschemistry.chemical_compoundpolyglycerolDrug Delivery SystemsCell Line TumorHumanslcsh:QH301-705.5Alkylchemistry.chemical_classificationLiposomeCholesterolBiological membraneMembranes ArtificialGeneral Medicine021001 nanoscience & nanotechnologyFlow CytometrybioconjugatesLipidsDynamic Light Scattering030104 developmental biologyMembranelcsh:Biology (General)chemistryMicroscopy FluorescenceDrug deliveryclick chemistrydrug deliveryBiophysicslipids (amino acids peptides and proteins)0210 nano-technologyLipoproteindescription
Lipid exchange among biological membranes, lipoprotein particles, micelles, and liposomes is an important yet underrated phenomenon with repercussions throughout the life sciences. The premature loss of lipid molecules from liposomal formulations severely impacts therapeutic applications of the latter and thus limits the type of lipids and lipid conjugates available for fine-tuning liposomal properties. While cholesterol derivatives, with their irregular lipophilic surface shape, are known to readily undergo lipid exchange and interconvert, e.g., with serum, the situation is unclear for lipids with regular, linear-shaped alkyl chains. This study compares the propensity of fluorescence-labeled lipid conjugates of systematically varied lengths to migrate from liposomal particles consisting mainly of egg phosphatidyl choline 3 (EPC3) and cholesterol into biomembranes. We show that dialkyl glyceryl lipids with chains of 18&ndash
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-09-01 | Cells |