6533b821fe1ef96bd127c399
RESEARCH PRODUCT
Investigating candidate neuromodulatory systems underlying parasitic manipulation: concepts, limitations and prospects.
Frank CézillyMarie-jeanne Perrot-minnotsubject
0106 biological sciences[ SDV.MP.PAR ] Life Sciences [q-bio]/Microbiology and Parasitology/ParasitologyNeuroimmunomodulationPhysiologyMultidisciplinary studyAquatic ScienceBiology010603 evolutionary biology01 natural sciencesHost-Parasite Interactions03 medical and health sciences[ SDV.EE.IEO ] Life Sciences [q-bio]/Ecology environment/SymbiosisAnimalsHumansParasites[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/ParasitologyParasite transmissionMolecular BiologyEcology Evolution Behavior and Systematics030304 developmental biologyethopharmacologyBehavior0303 health sciences[ SDE.BE ] Environmental Sciences/Biodiversity and EcologyneuroethologypsychoneuroimmunologyBiological evolutionBiological EvolutionserotoninInsect Sciencephenotypic engineeringAnimal Science and Zoology[SDE.BE]Environmental Sciences/Biodiversity and EcologyNeurosciencebehavioural manipulation[SDV.EE.IEO]Life Sciences [q-bio]/Ecology environment/Symbiosisdescription
Summary Studies addressing the functional basis of parasitic manipulation suggest that alteration of the neuromodulatory system is a common feature of manipulated hosts. Screening of the neuromodulatory system has so far been carried out by performing ethopharmacological analysis, biochemical quantification of neurotransmitters and neuromodulators, and/or immunocytochemistry. Here, we review the advantages and limitations of such approaches through the analysis of case studies. We further address whether the analysis of candidate neuromodulatory systems fits the current view of manipulation as being multidimensional. The benefits in combining ethopharmacology with more recent molecular tools to investigate candidate neuromodulatory pathways is also emphasized. We conclude by discussing the value of a multidisciplinary study of parasitic manipulation, combining evolutionary (parasite transmission), behavioural (syndrome of manipulation) and neuroimmunological approaches.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-12-11 |