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RESEARCH PRODUCT
(o-Hydroxyphenyl)methylphosphonic acids: Synthesis and potentiometric determinations of their pKaValues
Salah ChafaaJean MeullemeestreVolker BöhmerMarie-josé SchwingF. VierlingWalter Vogtsubject
Steric effectsChemistryOrganic ChemistryPotentiometric titrationRing (chemistry)BiochemistryMedicinal chemistryCatalysisInorganic Chemistrychemistry.chemical_compoundHydrolysisDrug Discoveryheterocyclic compoundsHydroxymethylPhenolsPhysical and Theoretical Chemistrydescription
(o-Hydroxyphenyl)methylphosphonic acids are readily obtained from o-(bromomethyl)- or o-(hydroxymethyl)phenols and trialkyl phosphites. Subsequent hydrolysis leads to the corresponding phosphonic acids. For a series of such compounds, the pKa values have been determined by potentiometry. Their dependence on additional substituents in the aromatic ring is discussed in terms of electronic and steric effects.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-02-10 | Helvetica Chimica Acta |