6533b822fe1ef96bd127ce3e

RESEARCH PRODUCT

Stereochemistry of terpene derivatives. Part 7: Novel rigidified amino acids from (+)-3-carene designed as chiral GABA analogues

Tadeusz LibrowskiJolanta PękalaKamila GajcyStanisław LochyńskiBożena Frąckowiak-wojtasek

subject

chemistry.chemical_classificationChemistryStereochemistryGABAA receptorMonoterpeneOrganic ChemistryCareneCatalysisAmino acidInorganic ChemistryTerpenechemistry.chemical_compoundnervous systemOrganic chemistryPhysical and Theoretical Chemistry

description

Abstract Several novel cyclopropyl-rigidified γ- and δ-amino acids 3 – 4 have been prepared starting from monoterpene (+)-3-carene 2 . These compounds are proposed as chiral analogues of γ-aminobutyric acid (GABA) 1 and are expected to be of interest as potential inhibitors of GABA receptors.

yearjournalcountryeditionlanguage
2010-08-01Tetrahedron-Asymmetry
10.1016/j.tetasy.2010.06.026https://doi.org/10.1016/j.tetasy.2010.06.026