6533b822fe1ef96bd127ceb9
RESEARCH PRODUCT
The unilateral nigral lesion induces dramatic bilateral modification on rat brain monoamine neurochemistry
Ennio EspositoArcangelo BenignoVincenzo Di MatteoMassimo PierucciGiuseppe CrescimannoGiuseppe Di Giovannisubject
Malemedicine.medical_specialtyParkinson's diseaseChromatography High pressure liquidRats as laboratory animalsHippocampusStriatumGeneral Biochemistry Genetics and Molecular BiologyBrain stemLesionRats Sprague-Dawleychemistry.chemical_compoundbrain monoamineHistory and Philosophy of ScienceDopamineInternal medicineCerebellummedicineunilateral nigral lesionAnimalsNeurochemistryratBiogenic MonoaminesOxidopamineChromatography High Pressure Liquidbusiness.industryGeneral NeuroscienceBrainCerebral cortexRatsSubstantia NigraMonoamine neurotransmitterEndocrinologychemistrynervous systemSerotoninmedicine.symptombusinessHippocampus (Brain)NeuroscienceOxidopaminemedicine.drugdescription
6-Hydroxydopamine (6-OHDA) is a neurotoxic compound commonly used to induce dopamine (DA) depletion in the nigrostriatal system, mimicking Parkinson's disease (PD) in animals. The aim of the present study was to evaluate the 7-day effect of unilateral nigral lesion on rat brain monoamine neurochemistry. Five brain regions were examined: the brain stem, cerebellum, hippocampus, striatum, and cortex. 6-OHDA-unilateral lesion dramatically modified DA, serotonin (5-HT) and their metabolites contents in both sides of the different brain nuclei. Furthermore, unilateral 6-OHDA lesion reduced DA and 5-HT contents and produced a robust inversion of their turnover in the nonlesioned side compared to sham-operated rats. These data suggest that 6-OHDA unilateral nigral lesion produces bilateral monoamine level modifications, and this piece of evidence should be taken into account when one interprets data from animal models of unilateral PD.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-01 |