6533b822fe1ef96bd127cf1f
RESEARCH PRODUCT
Eight-membered heterocycles with two heteroatoms in a 1,5-relationship of interest in medicinal chemistry
Daniela CarboneStella CascioferroPatrizia DianaGirolamo CirrincioneBarbara Parrinosubject
15-Oxazocine15-DithiocinChemistryBiological activityBiological propertyHeteroatom15-Dioxocin15-ThiazocineEight-membered heterocycles with two heteroatoms 15Medicinal chemistryMedicinal chemistry15-Diazocinedescription
Abstract This review deals with 1,5-diheterocines that exhibited biological properties and covers comprehensively the literature from 2007 to the end of February 2019. Among the six possible heterocyclic systems belonging to the eight-membered rings with two heteroatoms, N, O, and S, five had derivatives showing pharmacological activities: 1,5-diazocines, 1,5-oxazocines, 1,5-thiazocines, 1,5-dioxocins, and 1,5-dithiocins. Instead, literature reported no articles dealing with 1,5-oxathiocins of interest in medicinal chemistry. In addition to uncondensed derivatives, 1,5-diheterocines fused to five- and six-membered carbocycles or heterocycles are covered. Bridged 1,5-diheterocines are covered as well.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 |