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RESEARCH PRODUCT
Interaction of Novel Metal Complexes with DNA: Synthetic and Structural Aspects
Philipp M. AntoniChiara Da PieveBernhard SpinglerAlfredo Medina-molnerMaria Grazia Santangelosubject
10120 Department of ChemistryMono- and dinuclear metal complexesMetal ions in aqueous solutionand dinuclear metal complexes1600 General ChemistrydnaBioinorganic chemistryZ-DNAMetalchemistry.chemical_compoundMono- and Dinuclear Metal ComplexeGuanosine monophosphate540 ChemistryQD1-999Pulsed EPRCrystal structureBioinorganic chemistryGeneral MedicineGeneral ChemistryZ-DNACombinatorial chemistrySettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)Chemistrychemistryvisual_artCrystal structuresNucleic acidvisual_art.visual_art_mediumMonoSynthetic ChemistryDNAZdescription
Metal ions bind to nucleic acids at various positions. This binding can be modulated by using metal complexes with appropriate ligands. Novel mono- and especially dinuclear metal complexes could be a powerful tool to detect rare, but still physiologically relevant, forms of DNA, e.g. the left-handed Z-DNA. In this review, our recent research activities in this area of bioinorganic chemistry are summarized. A special emphasis is laid on the synthetic challenges that arose upon the synthesis of the polyamine ligands. Further, some rather unusual approaches to elucidate the solution structure of copper bound to guanosine monophosphate with the help of pulsed EPR techniques like ENDOR and HYSCORE are described.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-03-01 |