Activation of self-renewal and meiotic genes in tumour cell lines resistant to genotoxic treatment

6533b822fe1ef96bd127d171

RESEARCH PRODUCT

Activation of self-renewal and meiotic genes in tumour cell lines resistant to genotoxic treatment

Kristīne Salmiņa

subject

Molecular Biology and Biochemistry reversible polyploidy atgriezeniska poliploīdija embrionālo cilmes šūnu gēni lymphoma cell lines limfomu šūnu līnijas DNA damage Dzīvās dabas zinātnes Bioloģija DNS bojājums embryonal stem cell genes

description

Pašatjaunošanās un meijotisko gēnu aktivācija pēc genotoksiskas apstrādes rezistentās audzēju šūnu līnijās Šajā darbā tika pētīta iespējamā saistība starp poliploīdijas un dzimumšūnu līnijai raksturīgo gēnu indukciju pēc pretvēža apstrādes atkarībā no TP53 statusa un audzēju šūnu rezistence pret DNS bojājumu. Pirmo reizi tika atrasta un citoloģiski raksturota galveno cilmestības transkripcijas faktoru OCT4, NANOG un SOX2 ekspresijas aktivācija, kas izraisīta pārkāpjot tetraploīdo barjeru pēc DNS bojājuma TP53 mutantās, bet ne funkcionālās audzēja šūnas, kā arī galvenā mejotiskā kohezīna REC8 ekspresija somatisko audzēja šūnu līnijās, kas apstrādātas ar jonizējošo starojumu vai topoizomerazes II inhibitoru etopozīdu. Turklāt šajā procesā atrasta arī autofāgijas loma. Kopumā, šie novērojumi raksturo TP53-mutantu audzēja šūnu izdzīvošanas stratēģiju pēc genotoksiskas apstrādes, izmantojot kodola reprogrammēšanu uz embronalitātei līdzīgu stāvokli. Atslēgvārdi: atgriezeniska poliploīdija, embrionālo cilmes šūnu gēni, limfomu šūnu līnijas, DNS bojājums.

year	journal	country	edition	language
2014-01-01

https://dspace.lu.lv/dspace/handle/7/4936

PEPhysical Sciences and Engineering
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