6533b822fe1ef96bd127d6d0

RESEARCH PRODUCT

The effect of long context exposure on cued conditioning and c-fos expression in the rat forebrain

subject

description

The c-fos expression was used to study the neural substrates of the cued fear conditioning acquisition, preceded by a short exposure versus a long exposure to the conditioning context. A long-context exposure (either during the night or during the day) prior to conditioning, was associated with low freezing in the learning test. Differences in the c-fos expression of CA1, CA3, BL Amygdala, LS and BNST were found between the short- or long-context groups with a pre-exposure before cued conditioning. Ce Amygdala showed no differences in the c-fos expression labeling. We reported the hippocampal c-fos activation during the cued fear conditioning acquisition. Specifically, the CA1 activation could be related with the context-US processing during the CS-US association acquisition, which might prove that the CS-US associations cannot be made without an integrated context participating. The results showed that a long-context exposure prior to cued conditioning produces an inhibition of the CR (freezing), and this phenomenon is related with a specific c-fos expression in CA1, CA3, BL Amygdala, LS and BNST during the fear acquisition.