6533b822fe1ef96bd127d7de
RESEARCH PRODUCT
Pseudouridine: Still mysterious, but never a fake (uridine)!
Yuri MotorinMark HelmFelix Spenkuchsubject
RNA MitochondrialSaccharomyces cerevisiaeReviewBiologyModified nucleosidesPseudouridine03 medical and health scienceschemistry.chemical_compound0302 clinical medicineRNA modificationEscherichia coliHumansRNA Processing Post-Transcriptional[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM]Intramolecular TransferasesUridineMolecular Biology030304 developmental biology0303 health sciencesRNACell BiologyRNA Transfer Amino Acid-SpecificRibonucleoproteins Small NuclearUridineIsoenzymeschemistryBiochemistryRNA Ribosomal030220 oncology & carcinogenesisTransfer RNANucleic Acid ConformationRNARibosomesNucleosidePseudouridineSmall nuclear RNA[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyRNA Guide Kinetoplastidadescription
International audience; Pseudouridine () is the most abundant of >150 nucleoside modifications in RNA. Although was discovered as the first modified nucleoside more than half a century ago, neither the enzymatic mechanism of its formation, nor the function of this modification are fully elucidated. We present the consistent picture of synthases, their substrates and their substrate positions in model organisms of all domains of life as it has emerged to date and point out the challenges that remain concerning higher eukaryotes and the elucidation of the enzymatic mechanism.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-12-01 |