Ilgtermiņa išēmiska insulta sekas modeļa peļu smadzenēs: astrocītu un neiroblastu loma

6533b822fe1ef96bd127db6d

RESEARCH PRODUCT

Ilgtermiņa išēmiska insulta sekas modeļa peļu smadzenēs: astrocītu un neiroblastu loma

Jekaterina Pikaļova

subject

astrocīti Farmācija neiroblasti išēmisks insults neiroģenēze

description

Insults ir otrais galvenais nāves un visbiežākais invaliditātes cēlonis visā pasaulē. Išēmisks insults ir vissastopamākais insulta veids. Akūti išēmisks insults izraisa oksidatīvo stresu un eksitotoksicitāti, kas izraisa mikrogliju un astrocītu aktivāciju, izraisot citokīnu, matricas metaloproteināzes (MMP) un GFAP sekrēciju. Ir pieejami dati, par šiem procesiem, kas notiek un tiek aktivēti tieši išēmiska insulta akūta stadijā, savukārt dati par procesiem, kas notiek hroniskajā fāzē ir ļoti ierobežoti. Šī pētījuma mērķis bija noskaidrot, kā mainās astrocītu proteīna GFAP un neiroblastu marķiera dubultkortīna (DCX) ekspresija peļu smadzeņu hipokampā 6 mēnešus pēc eksperimentāla išēmiska insulta. Pētījumā iegūtie rezultāti parādīja, ka 6 mēnešus pēc išēmiska insulta inducēšanas peļu smadzeņu išemizētas puslodes hipokampā rajonā var novērot astrocītu skaita samazinājumu. Pētījumā ietvaros netika novērots specifisks signāls DCX antivielai. Nepieciešama tālāka izpēte, lai spriestu par astrocītu un neiroblastu savstārpējo mijiedarbību išēmiska insulta hroniskajā fāzē.

year	journal	country	edition	language
2022-01-01

https://dspace.lu.lv/dspace/handle/7/59790

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