Pepsinogēnu kā biomarķieru loma kuņģa vēža diagnostikā

6533b822fe1ef96bd127db73

RESEARCH PRODUCT

Pepsinogēnu kā biomarķieru loma kuņģa vēža diagnostikā

subject

Skrīnings Pepsinogēns H.pylori Medicīna Kuņģa vēzis

description

Pasaulē un Latvijā novēro augstus mirstības rādītājus kuņģa vēža gadījumā sakarā ar pārsvarā asimptomātisko slimības norisi un vēlīno diagnostiku. Invazīvas skrīninga metodes, kā endoskopija ar biopsiju veikšanu, ir efektīvas tikai augsta riska reģionos. Līdz ar to nepieciešams izstrādāt jaunas, efektīvas neinvazīvas skrīninga metodes. Visplašāk tiek pētīti pepsinogēnu testi, kas identificē pacientus ar kuņģa gļotādas atrofiju. Darba mērķis bija noteikt pepsinogēnu līmeņus kuņģa vēža pacientiem, tā izvērtējot šo biomarķieru efektivitāti kuņģa vēža pacientu identifikācijai. Pētījumā tika iekļauti 295 pacienti ar morfoloģiski apstiprinātu kuņģa vēža diagnozi. Pepsinogēnu līmeņi tika noteikti, izmantojot ELISA metodi. Rezultāti liecina, ka, izmantojot pepsinogēnu testus, divas trešdaļas kuņģa vēža pacientu netiktu identificētas.

year	journal	country	edition	language
2015-01-01

https://dspace.lu.lv/dspace/handle/7/30012

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