Ex Vivo Tracking of Endogenous CO with a Ruthenium(II) Complex.

6533b823fe1ef96bd127e0a7

RESEARCH PRODUCT

Ex Vivo Tracking of Endogenous CO with a Ruthenium(II) Complex.

Anita Toscani María José Alcaraz Ramón Martínez-máñez Cristina De La Torre Jonathan A. Robson Cristina Marín-hernández Andrew J. P. White Félix Sancenón María Carmen Terencio James D. E. T. Wilton-ely

subject

Stereochemistry Chemistry Multidisciplinary FLUORESCENT-PROBE Fluorescent-Probe chemistry.chemical_element Carbonylation Endogeny 010402 general chemistry Fluorogenic probes 01 natural sciences Biochemistry Catalysis chemistry.chemical_compound QUIMICA ORGANICA Colloid and Surface Chemistry Selective detection QUIMICA ANALITICA Carbon-Monoxide LIVING CELLS CARBON-MONOXIDE Science & Technology 010405 organic chemistry Air SELECTIVE DETECTION FLUOROGENIC PROBES AIR QUIMICA INORGANICA CARBONYLATION Living cells General Chemistry Fluorescence 0104 chemical sciences Ruthenium Chemistry chemistry Physical Sciences Biophysics Subcutaneous air HEME OXYGENASE-1 03 Chemical Sciences Carbonylation Heme Oxygenase-1 Ex vivo Carbon monoxide Palladium

description

[EN] A two-photon fluorescent probe based on a ruthenium(II) vinyl complex is capable of selectively detecting carbon monoxide in cells and ex vivo using mice with a subcutaneous air pouch as a model for inflammation. This probe combines highly selective and sensitive ex vivo detection of endogenous CO in a realistic model with facile, inexpensive synthesis, and displays many advantages over the widely used palladium-based systems.

year	journal	country	edition	language
2017-11-28	Journal of the American Chemical Society

10.1021/jacs.7b11158 https://pubmed.ncbi.nlm.nih.gov/29182272

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