6533b823fe1ef96bd127e280

RESEARCH PRODUCT

Copper-catalyzed regioselective synthesis of (E)-β-fluorovinyl sulfones

Daniel M. SedgwickPablo BarrioNatalia MateuSantos FusteroRaquel Román

subject

Vinyl CompoundsPharmaceutical Sciencealkynyl sulfonesChemical synthesisArticleCatalysisAnalytical ChemistrySulfonelcsh:QD241-441chemistry.chemical_compoundlcsh:Organic chemistryorganofluorine chemistryDrug DiscoveryOrganic chemistryPhysical and Theoretical Chemistrycopper catalysisMolecular StructureOrganic ChemistryRegioselectivityFluorineHydrogen fluorideOrganofluorine chemistryβ-fluorovinyl sulfonechemistryChemistry (miscellaneous)regioselectivityCopper catalyzedMolecular MedicineOrganofluorine compoundshydrogenationCopper

description

Organofluorine compounds are finding increasing application in a variety of fields such as pharmaceutical, agrochemical, and material sciences. However, given the scarcity of fluorine-containing natural products, advancement in this area depends almost entirely on the development of new synthetic methodologies. In this article, we present the synthesis of a series of previously undescribed (E)-&beta

yearjournalcountryeditionlanguage
2019-04-20
10.3390/molecules24081569http://hdl.handle.net/10651/52375