6533b823fe1ef96bd127e32c
RESEARCH PRODUCT
Injectable in situ forming microgels of hyaluronic acid-g-polylactic acid for methylprednisolone release
Calogero FioricaGiovanna PitarresiGaetano GiammonaGaetano GiammonaFilippo CalascibettaFabio Salvatore PalumboMauro Di Stefanosubject
Drugchemistry.chemical_classificationMaterials sciencePolymers and Plasticsmedia_common.quotation_subjectOrganic ChemistryGeneral Physics and Astronomymicrogels hyaluronic acid methylprednisolone drug delivery systemGraftingPolysaccharidechemistry.chemical_compoundPolylactic acidchemistryMethylprednisoloneHyaluronidaseSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoPolymer chemistryHyaluronic acidMaterials ChemistrymedicineCopolymermedicine.drugmedia_commonNuclear chemistrydescription
Abstract A hydrophobic derivative of hyaluronic acid (HA), obtained by grafting polylactic acid (PLA) to the polysaccharide, has been exploited to produce injectable in situ forming microgels. First of all, self assembling properties of HA-g-PLA copolymer have been evaluated by determining the critical aggregation concentration (CAC) value, then this copolymer has been dissolved in a mixture water/NMP 5:2 v/v with a concentration greater than CAC. When solutions at 1% or 2% w/v were injected into Dulbecco phosphate buffer solution (DPBS) pH 7.4, microgels promptly are formed. Their stability in DPBS pH 7.4 in the absence or in the presence of hyaluronidase and cell compatibility have been evaluated, as well as the ability to entrap a hydrophobic drug and to prolong its release. At this aim it has been chosen methylprednisolone, a drug employed for the treatment of osteoarthritis. Obtained results suggest the potential use of these in situ forming microgels for the intraarticular administration of antiinflammatory drugs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-03-01 |