6533b823fe1ef96bd127ea8d
RESEARCH PRODUCT
ChemInform Abstract: Addition of Organolithium Reagents to Cinnamic Acids.
María-josé BañulsRamon MestresElena MuñozMaría José Aurellsubject
chemistry.chemical_compoundAddition reactionChemistryReagentButyllithiumElectronic effectSubstituentComposition (visual arts)General MedicineMedicinal chemistryDiphenylmethane derivativesdescription
Abstract Reaction of tert -butyllithium with p - and m -substituted cinnamic acids at low temperature affords mixtures of 1,4- and 1,3-addition products, whose composition depend on the nature of the substituents. Electron-donating and electron-withdrawing groups favour 1,4- and 1,3-additions, respectively. Linear correlations are obtained with electronic effect and with radical substituent constants.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-06-15 | ChemInform |