6533b823fe1ef96bd127f47a

RESEARCH PRODUCT

Immobilization of functionalized lipids in a random poly(methacrylate) copolymer monolayer

Klaus LowackChristiane A. Helm

subject

Amphiphilic moleculeMaterials scienceMethacrylate copolymerMechanical EngineeringSubstituentMethacrylatePoly methacrylateAmorphous solidchemistry.chemical_compoundchemistryMechanics of MaterialsPolymer chemistryMonolayerCopolymerlipids (amino acids peptides and proteins)General Materials Science

description

It is shown that a monolayer of random poly(methacrylate) copolymer with a hydrophobic and a hydrophilic substituent exhibits a transition from the fluid to amorphous state. Above this transition any amphiphilic molecules mixed with the monolayer are immobile. Furthermore, such functionalized lipids are immobilized in the monolayer during the Langmuir-Blodgett transfer. The hydrophilic head-groups of the biotin-lipids remain on the formerly water-adjacent side of the monolayer, even if this side is exposed to air

https://doi.org/10.1002/adma.19950070211