6533b823fe1ef96bd127f4d4

RESEARCH PRODUCT

Genomics Meets Cancer Immunotherapy

Martin LoewerValesca BoisguerinSebastian BoegelThomas BukurJohn C. Castle

subject

Human leukocyte antigen typeCancer immunotherapyImmunogenic tumormedicine.medical_treatmentPik3ca mutationmedicineGenomicsHuman leukocyte antigenComputational biologyBiologyGenomeCancer immunology

description

High-throughput cancer genomics and bioinformatics are revolutionizing our ability to profile tumor samples. With next-generation sequencing (NGS) and high-performance computing (HPC) platforms, we have developed the infrastructures to determine and characterize tumor genomes and transcriptomes within days. Now, we are integrating these platforms into both cancer immunology and patient therapy decision-making. Here, we briefly describe the technology platforms and highlight several emerging applications: profiling of tumor mutations and gene expression; determination of HLA type and tumor expression, enabling prediction of immunogenic tumor mutations; and identification of viruses present in tumors. These and other concepts will continue to expand the medical impact of NGS.

yearjournalcountryeditionlanguage
2014-01-01
https://doi.org/10.1007/978-3-319-05104-8_22