Imunomodulatora glikoproteīna iedarbības novērtējums imūnšūnu un ādas šūnu kultūrās

6533b823fe1ef96bd127fa38

RESEARCH PRODUCT

Imunomodulatora glikoproteīna iedarbības novērtējums imūnšūnu un ādas šūnu kultūrās

Elīna Krūmiņa

subject

description

Bakalaura darba ietvaros in vitro analizēta Penicillium lanoso-viride glikoproteīna, AMP dezamināzes (AMPD), ietekme uz citokīnu un matriksa metaloproteināžu (MMP) sekrēciju, šūnas ciklu un migrāciju, lai spriestu par tā izmantošanas potenciālu ādas reģenerācijā. Pētāmā glikoproteīna ietekme tika novērtēta: dermas fibroblastos, HaCaT keratinocītos un perifēro asiņu mononukleārajās šūnās (MNC). Darbā iegūtie rezultāti parāda, ka AMPD inducē gan iekaisuma citokīnu, gan pretiekaisuma citokīna IL-10 sekrēciju MNC šūnās, tajā pašā laikā AMPD piemīt spēja regulēt LPS ierosinātu iekaisuma efektu. Keratinocītu migrāciju ievērojami paaugstina, ne tikai AMPD klātbūtne kultivēšanas vidē, bet vēl vairāk ar AMPD inducētu MNC šūnu kultivēšanas vides, norādot uz imūnmediēto keratinocītu stimulēšanu. Darbs tika izstrādāts Paula Stradiņa klīniskās universitātes slimnīcas Šūnu transplantācijas centrā no 2014. gada februāra līdz 2014. gada maijam.

year	journal	country	edition	language
2014-01-01

https://dspace.lu.lv/dspace/handle/7/18959

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
  - PE2_3Experimental particle physics with accelerators
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  - PE2_6Nuclear, hadron and heavy ion physics
  - PE2_8Gas and plasma physics
  - PE2_5Classical and quantum physics of gravitational interactions
  - PE2_7Nuclear and particle astrophysics
  - PE2_9 Electromagnetism
  - PE2_10Atomic, molecular physics
  - PE2_11Ultra-cold atoms and molecules
  - PE2_18Equilibrium and non-equilibrium statistical mechanics: steady states and dynamics
  - PE2_14Lasers, ultra-short lasers and laser physics
  - PE2_17Metrology and measurement
  - PE2_16Non-linear physics
  - PE2_12Optics, non-linear optics and nano-optics
  - PE2_13Quantum optics and quantum information
  - PE2_15Thermodynamics
- PE1Mathematics
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  - PE1_6Geometry and global analysis
  - PE1_8Analysis
  - PE1_7Topology
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LSLife Sciences
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SHSocial Sciences and Humanities
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