Ogļskābes arhidrāzes IX ekspresija gaišo šūnu nieru karcinomas šūnās

6533b823fe1ef96bd127fa3a

RESEARCH PRODUCT

Ogļskābes arhidrāzes IX ekspresija gaišo šūnu nieru karcinomas šūnās

Agnese Rudzīte

subject

gaišo šūnu nieru karcinoma plūsmas citometrija nieru karcinoma Farmācija ogļskābes anhidrāze IX

description

Gaišo šūnu nieru karcinoma mūsdienās ir viens no visbiežāk diagnosticētajiem audzēju veidiem, un, lai gan mirstība no tās samazinās, pašlaik terapijā lietoto medikamentu efektivitāte ir zema. Viens no iemesliem ķīmijterapijas neefektivitātei un ccRCC invazivitātei ir paaugstināta ogļskābes anhidrāzes IX ekspresija. Šajā pētījumā, izmantojot plūsmas citometriju, tika analizēta CA IX ekspresija gaišo šūnu nieru karcinomas šūnu līnijas un primārajās no pacienta izdalītajās ccRCC šūnās. Pētījumā tika apstiprināts zinātniskajā literatūrā aprakstītais, ka ccRCC šūnu līnijā (RCC-MF) attiecībā pret nieru proksimālo kanāliņu šūnu līniju (RC-124) ir novērojama paaugstināta CA IX ekspresija šūnu membrānās, taču, analizējot primārās ccRCC šūnas, CA IX ekspresijas izmaiņas netika novērotas, norādot uz atšķirīgo CA IX ekspresijas profilu no pacienta iegūtajās primārajās šūnās, kas precīzāk reprezentē audzēja heterogenitāti.

year	journal	country	edition	language
2019-01-01

https://dspace.lu.lv/dspace/handle/7/47833

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