6533b823fe1ef96bd127fdee

RESEARCH PRODUCT

ChemInform Abstract: Asymmetric Allylation/Ring Closing Metathesis: One-Pot Synthesis of Benzo-Fused Cyclic Homoallylic Amines. Application to the Formal Synthesis of Sertraline Derivatives.

Elsa RodríguezSantos FusteroRuben LazaroLidia HerreraPablo BarrioNatalia Mateu

subject

Formal synthesisRing-closing metathesisChemistryOne-pot synthesisSalt metathesis reactionGeneral MedicineMetathesisCombinatorial chemistry

description

A stepwise process consisting of asymmetric allylation of imines of type (I) and following ring-closing metathesis of the resulting dienes (III) is developed to synthesize cyclic homoallylic amines.

https://doi.org/10.1002/chin.201349107