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RESEARCH PRODUCT

Metabolic Activation and Pharmacokinetics in Hazard Assessment of Halogenated Ethylenes

R.j. LaibH. M. BoltJ. G. Filser

subject

chemistry.chemical_compoundchemistryVinyl bromideOrganic chemistryMedicinal chemistryVinyl chloride

description

Halogenated ethylenes play an important role in occupational and environmental medicine. Several attempts at toxicological evaluation of such compounds have been recently published (Maltoni 1977; Lee et al. 1978; Gehring et al. 1979; Kappus and Ottenwalder 1980; Henschler et al. 1980; Bolt 1980). The principal question is that of possible carcinogenicity. It is now clear that vinyl chloride (Maltoni 1977) and vinyl bromide (Bolt et al. 1979) are carcinogenic; some data also argue in favor of carcinogenicity of vinylidene chloride (Lee et al. 1978). Trichloroethylene (Henschler et al. 1980) and perchloroethylene (Bolt and Link 1980), according to present data, appear devoid of cancerogenic potency. These differences in biological behavior of such closely related compounds can only be explained on a biochemical basis (Bonse and Henschler 1976).

yearjournalcountryeditionlanguage
1981-01-01
https://doi.org/10.1007/978-3-642-68195-0_18