6533b824fe1ef96bd1280006

RESEARCH PRODUCT

Human FOXP3 and cancer.

François GhiringhelliGrégoire MignotFrançois MartinSylvain LadoireLionel Apetoh

subject

Cancer ResearchRegulatory T cellchemical and pharmacologic phenomenaBiologyT-Lymphocytes RegulatoryEpigenesis GeneticInterleukin 21AntigenNeoplasmsGeneticsmedicineCytotoxic T cellHumansGenes Tumor SuppressorIL-2 receptorMolecular BiologyZAP70FOXP3hemic and immune systemsForkhead Transcription FactorsNatural killer T cellPrognosismedicine.anatomical_structureGene Expression RegulationImmunologyCancer researchDNA Damage

description

FOXP3 is a transcription factor necessary and sufficient for induction of the immunosuppressive functions in regulatory T lymphocytes. Its expression was first considered as specific of this cell type, but FOXP3 can also be transiently expressed in T-cell antigen receptor-activated human nonregulatory T cells. Recent data indicate that FOXP3 is also expressed by some nonlymphoid cells, in which it can repress various oncogenes that are restored following FOXP3 deletion or mutation. This review summarizes major advances in (1) the understanding of Foxp3 functions in human regulatory T cells, (2) the prognostic significance of Foxp3-expressing T cells in human malignancies and (3) the significance of Foxp3 expression in human tumor cells.

yearjournalcountryeditionlanguage
2010-05-24Oncogene
10.1038/onc.2010.174https://pubmed.ncbi.nlm.nih.gov/20498631