6533b824fe1ef96bd1280122
RESEARCH PRODUCT
Cytokines and their effects on maturation, differentiation and migration of dendritic cells.
Juergen KnopHelmut JonuleitAlexander Enksubject
Langerhans cellLymphoid Tissuemedicine.medical_treatmentCellular differentiationDermatologyDendritic cell differentiationBiologyCell MovementmedicineAnimalsHumansProgenitor cellAntigen PresentationEpidermis (botany)Stem CellsCell DifferentiationGeneral MedicineDendritic cellDendritic CellsCell biologymedicine.anatomical_structureCytokineLangerhans CellsAntigens SurfaceCytokinesBone marrowdescription
In this review the role of cytokines in the maturation and migration of phenotypically and functionally diverse dendritic cell (DC) subpopulations is discussed and their role in the progress of differentiation from bone marrow progenitors to lymphoid DC is described. GM-CSF is the most important cytokine for the development of functional DC and acts in concert with a varying mixture of other cytokines such as IL-4, IL-1 and TNF-α to direct the development of individual DC subpopulations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1996-12-13 | Archives of dermatological research |