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RESEARCH PRODUCT
CXCR5 identifies a subset of Vγ9Vδ2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production
Francesco DieliLuca BattistiniRichard A. KroczekCarmela La MendolaAlfredo SalernoSerena MeravigliaEmmanuel ScotetFabrizio PocciaMarc BonnevilleJean-jacques FourniéGiovanna BorsellinoNadia Caccamosubject
AdultAntigens Differentiation T-LymphocyteMaleReceptors CXCR5T-LymphocytesCD40 LigandImmunologyCell CommunicationBiologyInducible T-Cell Co-Stimulator ProteinInterleukin 21medicineHumansImmunology and AllergyCytotoxic T cellIL-2 receptorAntigen-presenting cellB cellB-LymphocytesLymphokineReceptors Antigen T-Cell gamma-deltaNatural killer T cellLymphocyte SubsetsInterleukin-10Cell biologymedicine.anatomical_structureImmunologyFemaleReceptors ChemokineInterleukin-4Immunologic MemoryMemory T celldescription
Abstract Vγ9Vδ2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of Vγ9Vδ2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5+Vγ9Vδ2 T cells as a distinct memory T cell subset with B cell helper function.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-10-04 |