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RESEARCH PRODUCT

Stir bar sorptive-dispersive microextraction for trace determination of triphenyl and diphenyl phosphate in urine of nail polish users

J. Javier SerranoAlberto ChisvertJosé GrauAndrea SeguraJuan L. Benedé

subject

Liquid Phase MicroextractionCosmetics010402 general chemistryMass spectrometry01 natural sciencesBiochemistryAnalytical Chemistrychemistry.chemical_compoundLimit of DetectionTandem Mass SpectrometryHumansDetection limitChromatographyIon exchangeBiphenyl Compounds010401 analytical chemistryOrganic ChemistryExtraction (chemistry)PlasticizerReproducibility of ResultsGeneral MedicineOrganophosphates0104 chemical sciencesNail polishchemistryLinear ModelsMagnetic nanoparticlesChromatography LiquidTriphenyl phosphate

description

Abstract This work describes a new analytical method useful for monitoring the human exposure to the endocrine-disrupting plasticizer triphenyl phosphate (TPP) via nail polish use. The method allows trace determination of this parent compound and its main metabolite, namely diphenyl phosphate (DPP), in urine samples of nail polish users. The method is based on a novel microextraction technique termed stir bar sorptive-dispersive microextraction (SBSDME) using a magnetic composite made of CoFe2O4 magnetic nanoparticles embedded into a mixed-mode weak anion exchange polymer (Strata™-X-AW), followed by liquid chromatography-tandem mass spectrometry (LC–MS/MS). The main parameters involved in the extraction procedure were evaluated and optimized. Under the optimized conditions, the method was successfully validated showing good linearity (at least up to 100 ng mL−1) and enrichment factors (17 and 30), limits of detection and quantification in the low ng L−1 range (1.9–17.1 ng L−1 and 6.3–57.1 ng L−1, respectively) and good intra- and inter-day precision (RSD

yearjournalcountryeditionlanguage
2018-10-31Journal of Chromatography A
https://doi.org/10.1016/j.chroma.2019.02.014