6533b824fe1ef96bd1280bf9
RESEARCH PRODUCT
The impact of the endogenous subtype on the familial aggregation of unipolar depression.
Michael PhilippThomas KlinglerDirk LichtermannJoachim HallmayerWolfgang Maiersubject
ProbandMalemedicine.medical_specialtyEndogenybehavioral disciplines and activitiesDelusionsArousalDiagnosis DifferentialChild of Impaired ParentsRisk Factorsmental disordersmedicineHumansPharmacology (medical)PsychiatryBiological PsychiatryDepression (differential diagnoses)Depressive DisorderGeneral NeuroscienceMental DisordersFamily aggregationGeneral MedicineFamilial riskMiddle AgedCircadian RhythmPsychiatry and Mental healthNeuropsychology and Physiological PsychologyPhenotypeEndogenous depressionFemalePsychologyArousalClinical psychologydescription
The endogenous/non-endogenous distinction of unipolar major depression is widely accepted, as is the family study approach to the validation of diagnostic distinctions. Rates of affective disorders were examined in 689 first-degree relatives of 184 patients with unipolar major depression and were compared with 312 first-degree relatives of 80 healthy controls. Only unipolar depression and alcoholism were more common in families of depressed probands compared with families of healthy controls. As a variety of diagnostic definitions of endogenous depression have been proposed, probands and relatives were diagnosed in a polydiagnostic manner. None of the five diagnostic definitions of endogenous depression was able to identify patients with an increased familial risk of unipolar depression.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-06-01 | European archives of psychiatry and clinical neuroscience |