Peļu smadzeņu garozas mitohondriālās elpošanas novērtējums pēc vidējās cerebrālās artērijas oklūzijas

6533b824fe1ef96bd1280e6f

RESEARCH PRODUCT

Peļu smadzeņu garozas mitohondriālās elpošanas novērtējums pēc vidējās cerebrālās artērijas oklūzijas

Renāte Novicka

subject

peļu smadzeņu garozas audi vidējās cerebrālās artērijas oklūzijas modelis mitohondriālā skābekļa mērījumi Medicīna cerebrāls infarkts

description

Insults ir otrais vadošais nāves cēlonis un galvenais invaliditātes cēlonis pasaulē. Pētījumi parāda, ka smadzeņu mitohondriju funkciju traucējumiem ir svarīga nozīme cerebrālā infarkta patoģenēzē. Darba mērķis bija izpētīt cerebrālā infarkta ietekmi uz mitohondriālo elpošanu peļu smadzeņu garozas audos. Pētījuma rezultāti parādīja, ka vienu stundu pēc vidējās cerebrālās artērijas oklūzijas statistiski ticami intensīvāka mitohondriālā elpošana saistīta ar I un II kompleksu noris insulta grupas peļu smadzeņu kontralaterālās (insulta neskartās) puslodes garozas paraugos salīdzinot ar kontroles grupas kontralaterālās puses paraugiem. Iegūtie dati var liecināt par adaptīviem procesiem un metabolisma kāpumu insulta neskartajā puslodē. Nepieciešami plašāki cerebrālā infarkta izraisīto mitohondriālās elpošanas izmaiņu pētījumi.

year	journal	country	edition	language
2020-01-01

https://dspace.lu.lv/dspace/handle/7/51257

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