1,4-Dihidropiridīnu atvasinājumu nanodaļiņu toksiskuma novērtējums mikroorganismos

6533b824fe1ef96bd1280ee8

RESEARCH PRODUCT

1,4-Dihidropiridīnu atvasinājumu nanodaļiņu toksiskuma novērtējums mikroorganismos

subject

ATP nanodaļiņas etīdija bromīda transports toksicitātes novērtējums Bioloģija 1 4-dihidropiridīna atvasinājumi

description

1,4 Dihidropiridīnu (1,4 DHP) atvasinājumi ir plaša organisko vielu grupa, kurā arvien tiek sintezēti jauni savienojumi ar plašām pielietojuma iespējām. Jauno savienojumu toksicitātes raksturojums ir nepieciešams, lai paredzētu to pielietojuma iespējas un novērtētu to iedarbību uz vidi un dzīvajiem organismiem. Darbā pielāgota universāla un efektīva atšķaidījumu metode, lai noteiktu deviņu katjono amfifilo 1,4 DHP atvasinājumu toksicitātes robežkoncentrācijas sešām baktērijām un vienam raugam. Papildus noteikta 1,4 DHP atvasinājumu ietekme uz iekššūnas ATP daudzumu, skābekļa patēriņa ātrumu un etīdija bromīda transportu šūnās. Noskaidrojot toksicitātes robežkoncentrācijas un gūstot ieskatu potenciālajos toksicitātes faktoros, secināts, ka toksicitāti veido vairāku faktoru mijiedarbība.

year	journal	country	edition	language
2017-01-01

https://dspace.lu.lv/dspace/handle/7/36217

PEPhysical Sciences and Engineering
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