6533b824fe1ef96bd1281285
RESEARCH PRODUCT
Treatments for Opioid Dependence and Methadone
P.a. SáizJulio BobesManuel BousoñoMaría Teresa Bobes-bascaránM.t. BascaránSusana Al-halabíM.p. García-portillasubject
medicine.medical_specialtybusiness.industry(+)-NaloxoneNaltrexoneHeroinPharmacotherapyOpioidDetoxificationMedicinebusinessIntensive care medicineBuprenorphinemedicine.drugMethadonedescription
Abstract This chapter is focused on opioid dependence treatment and is framed in a holistic perspective. Specifically, there are three main approaches to pharmacological treatment of opioid dependence: opioid detoxification, agonist maintenance, and antagonist maintenance. There is a great amount of evidence supporting the efficacy of methadone and buprenorphine or the combination of buprenorphine–naloxone for the treatment of opioid withdrawal and their clinical utility as pharmacotherapy in long-term maintenance programs. Secondary or adjunctive medications such as heroin, naltrexone, and alpha-2-adrenergics are also reviewed. The need for further research and to overcome nonscientifically based barriers that prevent from developing and improving treatment resources, and the importance of managing comorbidity with other substances as well as other psychiatric illnesses, is briefly discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 |