6533b824fe1ef96bd12812cc
RESEARCH PRODUCT
Synthesis of a Naphtho-pyrido-Annulated Iodonium Salt and Pd-Catalyzed Transformation to 7H-Naphtho[1,8-bc][1,5]naphthyridine
Heiner DetertJulien LetessierMario GeffeDieter Schollmeyersubject
chemistry.chemical_classificationTransformation (genetics)ChemistryOrganic ChemistryNitroSalt (chemistry)chemistry.chemical_elementIodineMedicinal chemistryCatalysisAminationCatalysisPalladiumdescription
Nitropyridylnaphthalene is the central intermediate for the synthesis of naphthonaphthyridine and benzo-δ-carboline. Whereas the Cadogan reaction gives the carboline, transformation of the nitro group to iodo followed by oxidation and cyclization results in an iodonium salt. A twofold Pd-catalyzed amination leads to the naphthyridine.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-09-18 | Synthesis |