6533b824fe1ef96bd128137b

RESEARCH PRODUCT

ChemInform Abstract: The Reaction of 2,4,5,6-Tetraaminopyrimidine with Chalcones.

Herbert MeierBraulio InsuastyAlfredo PerezJairo QuirogaDiego Luis González

subject

Acetic acidchemistry.chemical_compoundDiazepineStereochemistryChemistryOrganic chemistryGeneral MedicineCondensation reactionCatalysis

description

The reaction of the tetraaminopyrimidine 1 with the chalcones 2a-f yields, in the presence of catalytic amounts of acetic acid, the 1H-pyrimido[4,5-b][1,4]diazepine derivatives 3a-f. The cyclization process consists of a condensation reaction and a Michael type addition.

https://doi.org/10.1002/chin.200027169