Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy

6533b824fe1ef96bd128159e

RESEARCH PRODUCT

Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy

Nicolò Mauro Gaetano Giammona Gennara Cavallaro Salvatore Emanuele Drago Emanuela Fabiola Craparo

subject

polyaspartamide lcsh:RS1-441 Pharmaceutical Science 02 engineering and technology Article lcsh:Pharmacy and materia medica 03 medical and health sciences chemistry.chemical_compound polyamine PEG ratio Copolymer pegylation Derivatization 030304 developmental biology STAT6 polyplexe chemistry.chemical_classification 0303 health sciences integumentary system Mucin polyplexes Biological membrane Polymer asthma 021001 nanoscience & nanotechnology chemistry siRNA Biophysics PEGylation Amine gas treating 0210 nano-technology

description

Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration. The polycation was synthesized by derivatization of &alpha

year	journal	country	edition	language
2020-01-22

10.3390/pharmaceutics12020089 http://hdl.handle.net/10447/395412

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