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RESEARCH PRODUCT
Hydrophilicity Regulates the Stealth Properties of Polyphosphoester‐Coated Nanocarriers
Frederik R. WurmJohanna SimonJohanna SimonVolker MailänderVolker MailänderThomas WolfKatharina LandfesterKatja Kleinsubject
Protein Corona02 engineering and technology010402 general chemistry01 natural sciencesCatalysisPolyethylene GlycolsMicechemistry.chemical_compoundDrug Delivery SystemsPEG ratioAnimalsHumanschemistry.chemical_classificationDrug CarriersMolecular StructureChemistryGeneral ChemistryPolymer021001 nanoscience & nanotechnology0104 chemical sciencesRAW 264.7 CellsBiophysicsPEGylationNanoparticlesNanocarriers0210 nano-technologyDrug carrierHydrophobic and Hydrophilic InteractionsEthylene glycolHeLa CellsProtein adsorptiondescription
Increasing the plasma half-life is an important goal in the development of drug carriers, and can be effectively achieved through the attachment of polymers, in particular poly(ethylene glycol) (PEG). While the increased plasma half-life has been suggested to be a result of decreased overall protein adsorption on the hydrophilic surface in combination with the adsorption of specific proteins, the molecular reasons for the success of PEG and other hydrophilic polymers are still widely unknown. We prepared polyphosphoester-coated nanocarriers with defined hydrophilicity to control the stealth properties of the polymer shell. We found that the log P value of the copolymer controls the composition of the protein corona and the cell interaction. Upon a significant change in hydrophilicity, the overall amount of blood proteins adsorbed on the nanocarrier remained unchanged, while the protein composition varied. This result underlines the importance of the protein type for the protein corona and cellular uptake.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-08 | Angewandte Chemie International Edition |