6533b824fe1ef96bd1281633
RESEARCH PRODUCT
Agrin in the Developing CNS: New Roles for a Synapse Organizer
Stephan KrögerJörn E. Schrödersubject
Central Nervous Systemmedicine.medical_specialtyanimal structuresAgrinPhysiologyRegeneration (biology)Central nervous systemSynaptogenesisBiologyHeparan Sulfate ProteoglycansNeuromuscular junctionSynapsemedicine.anatomical_structureEndocrinologynervous systemAlzheimer DiseaseInternal medicineSynapsesmedicineAnimalsHumansAgrinNeurosciencedescription
The heparan sulfate proteoglycan agrin is responsible for the formation, maintenance, and regeneration of the neuromuscular junction. In the central nervous system, agrin is widely expressed and concentrated at interneuronal synapses, but its function during synaptogenesis remains controversial. Instead, evidence for additional functions of agrin during axonal growth, establishment of the blood-brain barrier, and Alzheimer’s disease is accumulating.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-10-01 | Physiology |