Synthesis of vinca alkaloids and related compounds LX. A simple transformation of apovincamine into vincamine

6533b825fe1ef96bd1281cd0

RESEARCH PRODUCT

Synthesis of vinca alkaloids and related compounds LX. A simple transformation of apovincamine into vincamine

István Moldvai Csaba Szántay Kari Rissanen Csaba Szántay

subject

Vinca biology Alkaloid Organic Chemistry Vincamine Regioselectivity Apovincamine biology.organism_classification Biochemistry chemistry.chemical_compound Transformation (genetics)chemistry Drug Discovery medicine Organic chemistry Stereoselectivity Derivative (chemistry)medicine.drug

description

Abstract The 15α-chloro-vincamine derivative 2 was prepared and proved to be key intermediate of a two-step transformation of apovincamine into vincamine. The structure of 2 was established via detailed NMR and X-ray investigations.

year	journal	country	edition	language
1992-06-01	Tetrahedron

https://doi.org/10.1016/s0040-4020(01)81593-3

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