Synthesis of biotin-labelled dexamethasone derivatives. Novel hormone-affinity probes.

6533b825fe1ef96bd1281dac

RESEARCH PRODUCT

Synthesis of biotin-labelled dexamethasone derivatives. Novel hormone-affinity probes.

Hans-jörg Grill Irmgard Köhler Kunhard Pollow A. Heubner Bernhard Manz

subject

medicine.medical_treatment Biotin Biochemistry Binding Competitive Chromatography Affinity Dexamethasone Steroid chemistry.chemical_compound Glucocorticoid receptor Cytosol Receptors Glucocorticoid Affinity chromatography Biotin Cadaverine medicine Humans Binding site Receptor Polyacrylamide gel electrophoresis Chromatography Binding Sites Chemistry Splenic Neoplasms Affinity Labels Steroid hormone Biochemistry Electrophoresis Polyacrylamide Gel

description

A new, general methodology for 'sandwich' affinity chromatography of steroid hormone receptors is proposed, the part purification of the human spleen tumor glucocorticoid receptor is quoted as an illustration. 9-Fluoro-16 alpha-methyl-11 beta, 17-dihydroxy-1,4-androstadiene-3-one-17 beta-carboxylic acid was coupled to biotin using pentamethylenediamine (BioDex 1) as a spacer. The bifunctional derivative binds to glucocorticoid receptors and avidin-Sepharose and efficiently protects the glucocorticoid receptor against inactivation when previously added during homogenisation. We have standardized the capacity and optimum conditions for elution of receptor-BioDex-1 complexes which are bound to avidin-Sepharose. Receptor purification of several thousand fold can be obtained with good yield.

year	journal	country	edition	language
1983-03-01	European journal of biochemistry

10.1111/j.1432-1033.1983.tb07266.x https://pubmed.ncbi.nlm.nih.gov/6832154

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