6533b825fe1ef96bd1281e2f
RESEARCH PRODUCT
First total synthesis of antiostatin A1, a potent carbazole-based naturally occurring antioxidant.
Bernhard WitulskiDieter SchollmeyerCarole Alayracsubject
Antioxidantmedicine.medical_treatmentCarbazolesAlkyneAntioxidantsCatalysischemistry.chemical_compoundAntiostatin A1Materials ChemistrymedicineOrganic chemistryRhodiumchemistry.chemical_classificationMolecular StructureCarbazoleMetals and AlloysTotal synthesisRegioselectivityStereoisomerismGeneral ChemistryKey featuresSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialschemistryCyclizationCeramics and CompositesPalladiumdescription
The first total synthesis of the potent antioxidant antiostatin A1 is reported, where its key features rely on a chemo- and regioselective rhodium-catalysed crossed alkyne cyclotrimerisation reaction applying functionalised ynamides and a palladium-catalysed arylamidation reaction.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-03-12 | Chemical communications (Cambridge, England) |