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RESEARCH PRODUCT
Multisystem Amyloidosis in a Coal Miner with Silicosis: Is Exposure to Silica Dust a Cause of Amyloid Deposition?
Tomasz GołębiowskiJakub KuźniarTomasz PorażkoRenata WojtalaAndrzej KoniecznyMagdalena KrajewskaMarian Klingersubject
Health Toxicology and MutagenesisPublic Health Environmental and Occupational Healthsilicosis; primary amyloidosis; heart insufficiency; kidney insufficiency; proteinuriadescription
The over-secretion of monoclonal immunoglobulin light chains by clonal B cells followed by the aggregation and extracellular deposition of fibrillar deposits are responsible forthe clinical course AL amyloidosis. It is well documented that silica significantly increases the number of immunoglobulin-secreting cells. In the present paper, we report on a coal miner with silicosis and fast progressing primary amyloidosis with predominantly heart, kidney, and lung manifestations. Severeheart failure due to myocardial hypertrophy resulted in the patient’s death. We conclude that long-term environmental silica exposure and silica deposition may contribute to the development of monoclonal gammopathy and amyloidosis due to chronic stimulus and the dysregulation of the immune system.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-02-17 | International Journal of Environmental Research and Public Health |