6533b825fe1ef96bd12820b3
RESEARCH PRODUCT
Tuning the Basicity of Synergic Bimetallic Reagents: Switching the Regioselectivity of the Direct Dimetalation of Toluene from 2,5‐ to 3,5‐Positions
Victoria L. BlairWilliam CleggBen ConwayJan KlettRoss W. HarringtonLuca M. CarrellaLorna M. HoggLuca RussoRobert E. MulveyEva Rentschlersubject
alkali metalsMetalationInorganic chemistrychemistry.chemical_elementManganesemetalationmagnesium010402 general chemistry01 natural sciencesCatalysischemistry.chemical_compoundinverse crown compoundsBimetallic strip010405 organic chemistryRegioselectivityGeneral ChemistryGeneral MedicineAlkali metalCombinatorial chemistryTolueneCommunications3. Good health0104 chemical scienceschemistryReagentmanganesedescription
Meta-meta metalation: Remarkably, toluene can be directly dimanganated or dimagnesiated at the 3,5-positions using bimetallic bases with active Me3SiCH2 ligands (see scheme, blue). In contrast, n-butyl ligands lead to 2,5-metalation (red). tmp=2,2,6,6-tetramethylpiperidide.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-08-04 | Angewandte Chemie |