6533b825fe1ef96bd128274d

RESEARCH PRODUCT

Molecular characterization of α,β-poly(N-2-hydroxyethyl)-dl-aspartamide derivatives as potential self-assembling copolymers forming polymeric micelles

Gaetano GiammonaMariano LicciardiA. Giacometti SchieroniGennara CavallaroRaniero Mendichi

subject

chemistry.chemical_classificationMolar massMaterials sciencePolymers and PlasticsOrganic ChemistrySize-exclusion chromatographytechnology industry and agriculturemacromolecular substancesPolymerMicellechemistry.chemical_compoundchemistryCritical micelle concentrationPolymer chemistryMaterials ChemistryCopolymerMolar mass distributionlipids (amino acids peptides and proteins)Ethylene glycol

description

A family of graft copolymers derivatives obtained from α,β-poly(N-2-hydroxyethyl)-dl-aspartamide (PHEA) have been studied as potential self-assembling macromolecules forming stable polymeric micelles at low critical micellar concentration. These polymers are obtained grafting on PHEA poly(ethylene glycol) (PEG) (Mw 5000 g/mol) (PHEA–PEG), hexadecylamine (PHEA–C16) or both moieties (PHEA–PEG–C16). The PHEA derivatives were characterised by a multi-angle light scattering (MALS) photometer on line to a size exclusion chromatography system in obtaining the molar mass distribution of the polymers. In addition, to investigate the capacity to form micellar aggregates in aqueous medium the MALS photometer was used in off-line batch mode in obtaining molar mass and dimension of the polymeric aggregates.

yearjournalcountryeditionlanguage
2003-08-01Polymer
https://doi.org/10.1016/s0032-3861(03)00486-5