6533b825fe1ef96bd1282904

RESEARCH PRODUCT

DETERMINANTS OF DNA METHYLATION BASED AGE ACCELERATION IN YOUNG AND OLDER TWIN PAIRS

Kaprio JXiaoling WangMiina OIsmail KElina SillanpääT. Tormakangas

subject

Genetics03 medical and health sciencesAbstracts0302 clinical medicineHealth (social science)030214 geriatricsDNA methylationAcceleration (differential geometry)030212 general & internal medicineBiologyLife-span and Life-course StudiesHealth Professions (miscellaneous)

description

DNA methylation (DNAm) age, a novel marker of biological aging, has been shown to predict mortality and to be associated with physiological aging. However, the relative contribution of genetic and environmental factors to DNAm age over life span is not fully known. We estimated the magnitude of genetic and environmental factors in DNAm based age acceleration.

10.1093/geroni/igx004.4891https://europepmc.org/articles/PMC6184241/