Taksonomiskās izmaiņas zarnu mikrobioma sastāvā, lietojot metformīnu, pacientiem ar 2.tipa cukura diabētu

6533b825fe1ef96bd1282c92

RESEARCH PRODUCT

Taksonomiskās izmaiņas zarnu mikrobioma sastāvā, lietojot metformīnu, pacientiem ar 2.tipa cukura diabētu

Liene Gulbinska

subject

metformīns 16S rRNS zarnu mikrobioms Bioloģija 2.tipa cukura diabēts

description

Metformīns ir medikaments, kurš tiek plaši izmantots 2.tipa cukura diabēta (T2D) ārstēšanā un kura lietošanas laikā būtiski izmainās cilvēka zarnu mikrobioma baktēriju daudzveidība. Bakalaura darba mērķis bija raksturot ar metformīna īstermiņa terapiju asociētās taksonomiskās kompozīcijas izmaiņas zarnu mikrobiomā jaundiagnosticētiem T2D pacientiem. No 23 iesaistīto T2D pacientu fēču paraugiem tikai izdalīta mikrobiālā DNS, veikta mazās ribosomālās subvienības gēna (16S rRNS) V3 reģiona taksonomiskās kompozīcijas analīze ar lielapjoma paralēlo sekvenēšanu. Rezultātā novērota statistiski būtiskas atšķirības β-daudzveidībā un fenotipa specifiskas izmaiņu tendences baktēriju iekšējā daudzveidībā. Darbs tika veikts no 11.2016. līdz 05.2018. Latvijas Biomedicīnas un studiju centrā.

year	journal	country	edition	language
2018-01-01

https://dspace.lu.lv/dspace/handle/7/39648

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