6533b825fe1ef96bd1283102
RESEARCH PRODUCT
Molecular connectivity to find β-blockers with low toxicity
Lăcrămioara PopaJorge GalvezJ.v. De Julián-ortizC. De Gregorio AlapontRamón García-domenechsubject
Molecular modelLow toxicityChemistryStereochemistryOrganic ChemistryClinical BiochemistryProbucolPharmaceutical ScienceLinear discriminant analysisBiochemistryβ adrenoceptorDrug DiscoverymedicineMolecular Medicineβ adrenergic receptorMolecular Biologymedicine.drugdescription
Abstract Molecular connectivity has been used to find new β-blocker drugs using linear discriminant analysis and connectivity functions with different topological descriptors. Among the selected compounds stands out the probucol and the β-carotene. Both of them interact with β adrenoceptors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-03-01 | Bioorganic & Medicinal Chemistry Letters |