6533b825fe1ef96bd128310b

RESEARCH PRODUCT

Bovine lactoferrin pepsin hydrolysate exerts inhibitory effect on angiotensin I-converting enzyme-dependent vasoconstriction

Germán TorregrosaSalvador VallésJose F. MarcosJuan B. SalomPaloma ManzanaresMaría C. BurguetePedro Ruiz-giménezMaría Castelló-ruizEnrique Alborch

subject

chemistry.chemical_classificationmedicine.medical_specialtybiologyLactoferrinApplied Microbiology and BiotechnologyAngiotensin IIHydrolysateEnzymeEndocrinologychemistryInternal medicineRenin–angiotensin systemmedicinebiology.proteinmedicine.symptomReceptorVasoconstrictionEx vivoFood Science

description

Abstract The inhibitory effect of a pepsin hydrolysate of bovine lactoferrin (LFH) on angiotensin I-converting enzyme (ACE) has been examined using in vitro and ex vivo functional assays. In vitro assays showed a LFH inhibitory effect on ACE activity with an IC 50 value of 0.95±0.06 mg mL −1 . Ex vivo functional assays using rabbit carotid artery segments showed a LFH inhibitory effect on ACE-dependent angiotensin I-induced contraction, but not on angiotensin II-induced contraction, suggesting that the effect of LFH is not due to antagonism of receptors for angiotensin II. LFH was shown to possess ACE inhibitory effect with potential to modulate hypertension, although the possible inhibitory effect of LFH on angiotensinases deserves further research.

yearjournalcountryeditionlanguage
2007-10-01International Dairy Journal
https://doi.org/10.1016/j.idairyj.2007.03.013