6533b825fe1ef96bd1283201

RESEARCH PRODUCT

Influential Periods in Longitudinal Clinical Cardiovascular Health Scores

Mika KähönenLei LiuVito M. R. MuggeoAmy KrefmanR. Sue DayLiliana AguayoDonald M. Lloyd-jonesTomi T. LaitinenLydia A. BazzanoLarry S. WebberTerho LehtimäkiLinda Van HornNorrina B. AllenKatja PahkalaOlli T. RaitakariOlli T. RaitakariPhilip GreenlandMarkus JuonalaLindsay R. PoolDarwin R. Labarthe

subject

AdultMaleAdolescentEpidemiologyCardiovascular healthHealth Behavior3121 Internal medicineYoung AdultSex Factorscohort studiespreventionHumanslongitudinal studiesrisk factorsMedicineAcademicSubjects/MED00860Young adultChildAgedbusiness.industryAge Factorscardiovascular healthOriginal ContributionMiddle AgedLate adolescence3126 Surgery anesthesiology intensive care radiologyMiddle ageConfidence interval3142 Public health care science environmental and occupational healthBlood pressureHeart Disease Risk FactorsFemaleadolescencebusinessBody mass indexcardiovascular epidemiologyDemographyCohort study

description

Abstract The prevalence of ideal cardiovascular health (CVH) among adults in the United States is low and decreases with age. Our objective was to identify specific age windows when the loss of CVH accelerates, to ascertain preventive opportunities for intervention. Data were pooled from 5 longitudinal cohorts (Project Heartbeat!, Cardiovascular Risk in Young Finns Study, The Bogalusa Heart Study, Coronary Artery Risk Development in Young Adults, Special Turku Coronary Risk Factor Intervention Project) from the United States and Finland from 1973 to 2012. Individuals with clinical CVH factors (i.e., body mass index, blood pressure, cholesterol, blood glucose) measured from ages 8 to 55 years were included. These factors were categorized and summed into a clinical CVH score ranging from 0 (worst) to 8 (best). Adjusted, segmented, linear mixed models were used to estimate the change in CVH over time. Among the 18,343 participants, 9,461 (52%) were female and 12,346 (67%) were White. The baseline mean (standard deviation) clinical CVH score was 6.9 (1.2) at an average age of 17.6 (8.1) years. Two inflection points were estimated: at 16.9 years (95% confidence interval: 16.4, 17.4) and at 37.2 years (95% confidence interval: 32.4, 41.9). Late adolescence and early middle age appear to be influential periods during which the loss of CVH accelerates.

yearjournalcountryeditionlanguage
2021-11-02
10.1093/aje/kwab149https://trepo.tuni.fi/handle/10024/137211