6533b825fe1ef96bd1283350
RESEARCH PRODUCT
A critical period for experience-dependent remodeling of adult-born neuron connectivity.
Elisa MotoriKarl Kklaus ConzelmannMatteo BergamiMateo BergamiSung Min YangGiacomo MasserdottiMagdalena GötzAlejandro F. SchinderJana GöbelSilvio Gabriel TempranaTherese ErikssonBunedikt BerningerBunedikt Berningersubject
MaleTime FactorsCIENCIAS MÉDICAS Y DE LA SALUDNeurogenesisNeuroscience(all)NeurocienciasSynaptogenesisHippocampusMice TransgenicHippocampal formationEnvironmentMotor ActivityInhibitory postsynaptic potentialTransfectionCRITICAL PERIODADULT NEUROGENESISArticleMiceNeural PathwaysmedicineAnimalsSYNAPTOGENESISCells CulturedNeuronsEnvironmental enrichmentNeuronal PlasticityGeneral NeuroscienceDentate gyrusCritical Period PsychologicalNeurogenesisBrain//purl.org/becyt/ford/3.1 [https]Embryo MammalianMice Inbred C57BLENRICHED ENVIRONMENTLuminescent ProteinsMedicina Básicamedicine.anatomical_structurenervous system//purl.org/becyt/ford/3 [https]NeuronNerve NetPsychologyNeurosciencedescription
Neurogenesis in the dentate gyrus (DG) of the adult hippocampus is a process regulated by experience. To understand whether experience also modifies the connectivity of new neurons, we systematically investigated changes in their innervation following environmental enrichment (EE). We found that EE exposure between 2-6 weeks following neuron birth, rather than merely increasing the number of new neurons, profoundly affected their pattern of monosynaptic inputs. Both local innervation by interneurons and to even greater degree long-distance innervation by cortical neurons were markedly enhanced. Furthermore, following EE, new neurons received inputs from CA3 and CA1 inhibitory neurons that were rarely observed under control conditions. While EE-induced changes in inhibitory innervation were largely transient, cortical innervation remained increased after returning animals to control conditions. Our findings demonstrate an unprecedented experience-dependent reorganization of connections impinging onto adult-born neurons, which is likely to have important impact on their contribution to hippocampal information processing. Fil: Bergami, Mateo. University Hospital of Cologne; Alemania. Ludwig Maximilians Universitat; Alemania Fil: Masserdotti, Giacomo. Ludwig Maximilians Universitat; Alemania. Helmholtz Zentrum Munchen; Alemania Fil: Temprana, Silvio Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina Fil: Motori, Elisa. Max Planck Institute for Biology of Ageing; Alemania Fil: Eriksson, Therese M.. University Hospital of Cologne; Alemania Fil: Gobel, Jana. University Hospital of Cologne; Alemania Fil: Yang, Sung Min. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina Fil: Conzelmann, Karl Kklaus. Ludwig Maximilians Universitat; Alemania Fil: Schinder, Alejandro Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina Fil: Gotz, Magdalena. Ludwig Maximilians Universitat; Alemania. Helmholtz Zentrum Munchen; Alemania Fil: Berninger, Bunedikt. Ludwig Maximilians Universitat; Alemania. University Medical Center of the Johannes Gutenberg University; Alemania
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-02-01 |