6533b826fe1ef96bd12834e3
RESEARCH PRODUCT
A Cu-BOX catalysed enantioselective Mukaiyama-aldol reaction with difluorinated silyl enol ethers and acylpyridine
Amparo Sanz-marcoDaniel EsperillaMarc Montesinos-magranerCarlos VilaM. Carmen MuñozJosé R. PedroGonzalo Blaysubject
CatàlisiOrganic ChemistryPhysical and Theoretical ChemistryQuímica orgànicaBiochemistrydescription
A Cu(II)/BOX complex catalyses the enantioselective addition of difluorinated silyl enol ethers to acylpyridine N-oxides. The reaction provides difluorinated chiral tertiary alcohols of great interest in medicinal chemistry. These compounds are obtained in moderate to excellent yields and with high enantioselectivities. The stereochemical outcome of the reaction has been explained by DFT calculations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-12-10 | Organicbiomolecular chemistry |