6533b826fe1ef96bd1283a75

RESEARCH PRODUCT

Oxidative cyclization of some aldehyde semicarbazones induced by metallic salts

Paolo Lo MeoFrancesco BuccheriGiuseppe WerberMichelangelo GruttadauriaRenato NotoGiuseppe Cusmano

subject

chemistry.chemical_classificationOxidative cyclizationOrganic ChemistryRegioselectivityRing (chemistry)AldehydeMetalchemistry.chemical_compoundchemistryvisual_artYield (chemistry)Oxidizing agentPolymer chemistryvisual_art.visual_art_mediumSemicarbazone

description

The oxidative cyclization of some aldehyde semicarbazones 10 with four different oxidizing agents has been effected. The structure of the semicarbazones and the nature of cyclizing agent affected the rate and yield of cyclization but they did not show any influence on the regiochemistry of reaction. In fact, 1,2,4-triazoline 20 was the only heterocyclic ring obtained by the cyclization reaction.

https://doi.org/10.1002/jhet.5570300327