6533b826fe1ef96bd1283b1d

RESEARCH PRODUCT

Temporal and Spatial Evolution of Cortical Blood Flow in the Penumbra of Venous Infarcts

K. UedaH. OtsukaT. TakeshimaAxel HeimannOliver Kempski

subject

medicine.medical_specialtybusiness.industryPenumbraBlood flowLaser Doppler velocimetryArterial occlusionVein occlusionCerebral blood flowInternal medicineOcclusioncardiovascular systemmedicineCardiologySpatial evolutionbusiness

description

A cortical venous infarction model has been evaluated regarding the temporal and spatial evolution of regional flow reduction. Two cortical veins were occluded photochemically with rose bengal and fiberoptic illumination. Seven rats served to demonstrate effects on regional cortical blood flow using laser Doppler scanning. After two-vein occlusion, there was a widespread reduction of flow that gradually deteriorated after vein occlusion when regional cortical flow in a 3.5 x 7.0 mm window: after 15 min it had decreased to 57.8% ± 8.0%, and after 75 min it was 34.3% ± 5.4%. Infarct volumes as determined in 10 rats 5 days after two-vein occlusion had an average size of 3.6 ± 0.7 mm3. The data indicate that flow after two-vein occlusion resembles that seen under penumbra conditions. The core/penumbra ratio appears considerably lower than that observed after arterial occlusion. The model therefore appears particularly suited to study damage mechanisms responsible for infarct growth.

yearjournalcountryeditionlanguage
2001-01-01
https://doi.org/10.1007/978-4-431-67899-1_44